调解骨肌肉线粒体功能的非编码RNA分子及其在运动分子生理学中的潜在应用:系统性审查
Isaac A Chavez-Guevara1, Héctor Vázquez-Lorente2,3,4,5,6, Lourdes Herrera-Quintana2
1Faculty of Sports Campus Ensenada, Autonomous University of Baja California, Tijuana, Mexico.
American journal of physiology. Cell physiology
|November 25, 2025
概括
非编码RNAs (ncRNAs) 关键调节骨肌肉中的线粒体功能. 运动影响ncRNA的表达,为治疗代谢障碍提供了潜力.
科学领域:
- 分子生物学分子生物学
- 运动生理学 运动生理学
- 线粒体生物学 线粒体生物学
背景情况:
- 非编码RNAs (ncRNAs) 是基因表达的关键调节者.
- 线粒体功能障碍与各种代谢和与年龄有关的疾病有关.
- 骨肌肉线粒体在能量代谢和整体健康中发挥着关键作用.
研究的目的:
- 系统地审查ncRNAs在骨肌肉线粒体调节中的作用.
- 探索运动对ncRNA表达和线粒体功能的影响.
- 确定ncRNAs在运动分子生理学和疾病治疗中的潜在应用.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 包括来自2,378个记录的45项相关研究.
- 分析参与线粒体过程的ncRNAs,包括miRNAs,lncRNAs和circRNAs.
主要成果:
- 特定的miRNAs (例如,miR-133a,miR-696) 和lncRNAs显著调节线粒体生物发生,动力学和线粒体细胞衰变.
- 运动干预调节ncRNA表达,增强线粒体功能.
- 已识别的ncRNA显示出作为线粒体疾病的生物标志物和治疗点的潜力.
结论:
- ncRNAs是骨肌肉线粒体适应运动的关键参与者.
- 向ncRNAs可能为代谢和线粒体疾病提供新的治疗策略.
- 对肌肉特异性和运动模式特异性ncRNA效应进行进一步的研究是有必要的,以实现个性化干预.
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