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In Vitro Thrombosis Test for Ventricular Assist Devices
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儿童在医院获得的静脉血栓栓塞的绝对时间依赖风险
Maya K Raad1, Stephanie Prozora1, E Vincent S Faustino1
1Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Thrombosis research
|November 25, 2025
概括
这项研究准确地预测了儿童在医院获得的静脉血栓栓塞 (HA-VTE) 的绝对时间依赖风险. 这种预测工具可以帮助评估血栓预防的益处,并指导未来关于出血风险的研究.
科学领域:
- 儿科血栓瘤研究研究
- 临床风险预测建模模型
- 在医院获得的条件.
背景情况:
- 评估医院获得的静脉血栓塞栓症 (HA-VTE) 的绝对时间依赖风险对于确定儿科患者药理性血栓预防的临床净益处至关重要.
- 现有的儿童医院获得性血栓瘤 (CHAT) 风险评估模型 (RAM) 识别了儿科HA-VTE风险因素,但没有设计用于风险预测.
- 需要一个模型来准确预测住院儿童中HA-VTE的绝对时间依赖风险.
研究的目的:
- 开发和验证一个模型来预测住院儿童中HA-VTE的绝对时间依赖风险.
- 确定与这一群体中HA-VTE发展相关的关键风险因素.
- 提供一个工具,以便在儿科护理中更好地分层和管理HA-VTE的风险.
主要方法:
- 进行了一项单一中心病例队列研究,涉及2013年至2022年期间入院的年龄≤18岁的儿童.
- 确诊的,有症状的HA-VTE的儿童被确定为病例,5%的合格入院者随机抽样组成了子队列.
- 卡普兰-梅尔估计和考克斯回归,结合CHAT RAM风险因素,用于计算HA-VTE的绝对时间依赖风险,通过AUROC和AUPRC评估性能.
主要成果:
- 从23,287个入院病例中,共发现81名患有HA-VTE的儿童.
- 青少年年龄,运动能力有限,以及使用中央静脉导管与HA-VTE的时间有显著的关联.
- 在第12天,HA-VTE的中位数绝对时间依赖风险为1.7%,AUROC为0.81,表明良好的预测性能.
结论:
- 开发的模型准确地预测了住院儿童中HA-VTE的绝对时间依赖风险.
- 这些发现强调了在风险评估中考虑年龄,移动性和中央静脉导管使用等因素的重要性.
- 进一步的研究应该专注于开发类似的预测模型,用于儿科患者的出血事件.
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