调节改变的感觉预测使用双边听觉皮层高清横随机噪声刺激和声学掩盖
Zino H Wellauer1, Deniza Avdi2, Payam S Shabestari2
1Evolutionary Neuroscience of Language, Department of Comparative Language Science, University of Zurich, Zurich, Switzerland; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Switzerland; Neurorehabilitation Center, Klinik Lengg, Schweizerische Epilepsie Stiftung, Zurich, Switzerland; Center for the Interdisciplinary Study of Language Evolution, University of Zurich, Zurich, Switzerland.
概括
高分辨率的横随机噪声刺激 (HD-tRNS) 与声学刺激 (AS) 结合,显示出对耳治疗的前景. 这种方法调节了听觉唤起的潜力,并降低了感知到的耳声的响度,为听觉神经可塑性提供了新的见解.
科学领域:
- 听觉神经科学 听觉神经科学
- 神经可塑性 神经可塑性
- 耳研究研究 耳研究
背景情况:
- 慢性耳声通常与听觉系统处理的改变有关.
- 非侵入性脑刺激技术正在探索用于耳管理.
- 了解 tinnitus 的神经相关性对于开发有效疗法至关重要.
研究的目的:
- 评估高清超间随机噪声刺激 (HD-tRNS) 和声学刺激 (AS) 对听觉唤起潜能 (AEP) 和耳感知的综合影响.
- 调查双节刺激对慢性耳患者神经处理和噪音的影响.
主要方法:
- 这是一项双盲,随机,受控,主体内交叉试验,涉及13名患有慢性耳的成年人.
- 四个实验性会议:活跃的HD-tRNS + AS,单独的活跃的HD-tRNS,假的HD-tRNS +假的AS,单独的假的HD-tRNS.
- 每次会议前后测量AEP (包括不匹配负面性) 和耳特征.
主要成果:
- 与虚假条件相比,与AS显著调节的AEPS相结合的活性HD-tRNS.
- 双通道刺激改变了不匹配的消极幅度,可能抵消与耳相关的处理缺陷.
- 在双模和双模模模拟刺激时,观察到客观声音的显著降低 (>3dB).
结论:
- 高清tRNS,特别是与AS配对时,可以改变听觉系统的兴奋性.
- 这种联合刺激急剧改变了 tinnitus 患者的神经处理和噪音感知.
- 声学和电刺激的结合代表了听觉神经科学研究和临床应用的有希望的途径.
相关概念视频
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