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硫胺和三甲对兽医病原体的最低抑制度:对旧抗生素的新数据

Nadine Ruchti¹, Aude A Ferran², Andrew Mead³

¹Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland.

Veterinary microbiology

|November 25, 2025

概括

本研究确定了用trimethoprim-sulfamethoxazole和相关药物治疗的兽医病原体的最小抑制度分布. 这些发现有助于确定关键兽医抗生素的抗菌素耐药性标准.

科学领域:

兽医微生物学兽医微生物学
抗微生物耐药性抗微生物耐药性
药理学药理学是指药理学的学科.

背景情况:

对抗微生物敏感性测试 (AST) 的准确解释依赖于已确定的临床断点 (CBP) 或流行病学截止值 (ECOFF).
基本的第一线抗生素缺乏对兽医病原体的明确解释标准,这阻碍了有效的治疗和耐药性监测.
这种差距需要生成数据来确定这些关键值.

研究的目的:

为了确定兽医病原体的最小抑制度 (MIC) 分布,对抗三甲-硫甲醇 (1:19) 和单个硫胺/三甲.
估计特定细菌物种中对硫胺和三甲胺的微生物耐药性的流行率.
为潜在的QC菌株提出初步质量控制 (QC) 范围,并支持建立ECOFF.

主要方法:

根据欧洲抗菌感应性测试委员会 (EUCAST) 的指导方针使用的微稀释方法.
对于trimethoprim-sulfamethoxazole,sulfamethoxazole,sulfadiazine,sulfadimethoxine和trimethoprim来说,MIC分布被生成了.
数据分析的重点是满足ECOFF估计的EUCAST标准,并提出QC范围.

主要成果:

对于三甲-硫甲,硫甲和三甲的MIC分布符合EUCAST标准,允许对大多数病原体提出假定的ECOFF.
由于度范围不足,无法估计硫法迪亚辛和硫法迪美托克辛的假定ECOFF.
该研究确定了潜在的QC菌株候选者,并为未来的实验室间研究生成了必要的数据.

结论:

生成的MIC数据和针对三甲-硫甲醇,硫甲醇和三甲胺的建议ECOFF对于精确的兽医AST解释至关重要.
需要进行进一步的研究,以确定硫法迪亚和硫法迪美托克辛的ECOFF.
这项研究通过为制定监管标准提供基础,支持在治疗兽医感染中继续使用这些至关重要的第一线抗生素.

关键词:

抗微生物耐药性抗微生物耐药性抗微生物敏感性测试试验抗微生物敏感性测试流行病学界限值是指流行病学界限值.第一线抗生素是一种抗生素.苏尔法迪亚辛 (sulfadiazine) 是一种硫酸盐.硫法迪美托克辛 (sulfadimethoxine) 是一种硫化物.硫甲佐 (sulfamethoxazole) 是一种硫甲佐 (sulfamethoxazole) 的一种化合物.

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