香草酸通过调节氧化应激,炎症反应,巨细胞极化和AMPK信号通路来保护性结肠炎
Xiaojing Ma1, Changlong Ouyang2, Ping Tang2
1School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
International immunopharmacology
|November 25, 2025
概括
香草酸 (VA) 通过减少炎症和氧化应激,在治疗性结肠炎 (UC) 中表现有前途. 这种天然化合物可能为这种慢性炎症性肠病提供更安全,更可持续的治疗选择.
科学领域:
- 胃肠道学和免疫学
- 药理学和天然产品研究
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,影响生活质量.
- 目前对UC的治疗方法有局限性,包括副作用和复发率.
- 需要新的,可持续的,有毒性降低的治疗方法来管理UC.
研究的目的:
- 研究香草酸 (VA) 对性结肠炎 (UC) 的保护作用.
- 阐明VA在UC模型中的作用的基本机制.
主要方法:
- 在体外研究中,使用RAW 264.7和NCM460细胞治疗了脂多糖 (LPS) 和香草酸 (VA).
- 在体内研究使用硫酸 (DSS) 诱导的UC小鼠模型,并口服VA.
- 分析包括氧化应激标志物,炎症性细胞因子,肠道屏障蛋白和转录组测序 (KEGG通路分析).
主要成果:
- 乙烯酸 (VA) 减弱的LPS诱导的活性氧物种和超氧化离子在体外生产.
- 在刺激细胞中,VA降低了促炎标记物 (NFκB,IL-6,IL-1β) 和增加了肠道屏障蛋白 (Claudin-1,Occludin,ZO-1).
- 在体内,VA治疗减轻了DSS诱导的UC症状,包括减肥,结肠缩短和疾病活动,通过减少氧化应激,炎症和增强屏障完整性.
结论:
- 香草酸 (VA) 显示出对实验性性结肠炎 (UC) 的显著保护作用.
- 通过减轻氧化应激,抑制炎症,调节巨细胞两极分化,增强肠道屏障功能,VA可以改善UC.
- VA调节关键信号通路 (AMPK,PPAR) 和代谢过程,表明其在UC治疗中的治疗潜力.
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