个性化和标准化的基于晶圆的开放标签安慰剂可以减少大学生的感知压力:一个三臂随机对照试验
Johannes C Fendel1, Corinna Ketter2, Paulina Liese1
1Department of Psychosomatic Medicine and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Journal of psychosomatic research
|November 25, 2025
概括
可食用的开放标签安慰剂 (OLPs) 有效地降低了大学生的压力. 个性化的OLP还改善了焦虑,证明了心理干预的多功能交付方法.
科学领域:
- 心理学 心理学 心理学
- 临床心理学 临床心理学
- 健康心理学 心理健康心理学
背景情况:
- 开放标签安慰剂 (OLP) 没有欺骗,可以引起有益的影响.
- 这项研究研究了可食用的OLP晶圆,有或没有个性化指导,用于压力较大的大学生.
研究的目的:
- 为了评估与等待名单对照相比个性化的OLP在减少感知压力的有效性.
- 检查标准化的OLP的影响和个性化对压力和其他心理结果的额外好处.
主要方法:
- 一个优越性随机对照试验与137名高度压力大学生超过三个星期.
- 参与者被分配到个性化的OLP,标准化的OLP或等候名单控制中.
- 结果包括感知到的压力,焦虑,抑郁,睡眠,幸福感和生活满意度,在基线,干预后和随访时进行评估.
主要成果:
- 与等待名单相比,OLP两组的感知压力都显著降低,随访时效应保持.
- 只有在个性化的OLP组中才观察到焦虑的减少.
- 较低的一般自我效能预测了更大的抑郁减轻,更高的治疗预期预测了标准化的OLP手臂中更大的福祉收益.
结论:
- 可食用晶圆代表了开放标签安慰剂的有希望和多功能交付格式.
- 个性化和以机制为导向的改进具有优化临床和预防环境中的OLP干预的潜力.
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