太空相关的干细胞标志着宇航员的衰老和弹性
Jessica Pham1, Shuvro P Nandi2, Larisa Balaian1
1Sanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Cell stem cell
|November 25, 2025
概括
太空飞行会导致血液造血干细胞 (HSPC) 的可逆变化,影响生存和基因表达. 在长期太空任务之前,进一步的HSPC分析至关重要.
科学领域:
- 太空生物学空间生物学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 之前的研究指出,在太空飞行后出现了免疫和染色体问题.
- 太空旅行对造血干细胞和原生细胞 (HSPCs) 的影响及其弹性仍然未被研究.
研究的目的:
- 研究短期太空飞行对HSPC功能和弹性的影响.
- 分析来自宇航员的多omics数据,以了解太空引起的HSPCs变化.
主要方法:
- 对9名宇航员进行了HSPC功能性组织的多omics衰老和弹性 (HSPC-FOMA-R) 分析.
- 使用全基因组测序,全转录组测序,单细胞RNA测序,细胞因子阵列和FACS分析.
- 评估端粒长度,突变概况,RNA编辑,逆转移素活性和免疫细胞动态.
主要成果:
- 太空飞行导致HSPC生存,自我更新和细胞周期的部分可逆变化.
- 观察到对RNA1 (ADAR1),端粒维护和与应激反应相关的基因表达作用的腺胺酶的变化.
- 鉴定了克隆性造血突变,阿波利波蛋白B编辑mRNA的催化多类 (APOBEC3C) 激活,以及逆转移素放松调节.
结论:
- 太空飞行影响HSPC的功能和弹性,有些变化是可逆的.
- 在扩展太空任务之前,全面的HSPC-FOMA-R分析对于评估宇航员健康至关重要.
- 这些发现凸显了进一步研究太空飞行对造血系统的长期影响的必要性.
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