不对称的侧面膜功能和外围神经机制在调节引起的伤时起作用
Suna L Cranfill1, Huasheng Yu1, Yingqi Wang1
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Current biology : CB
|November 25, 2025
概括
研究人员发现,左侧大脑 (LHb) 抑制引起的. 这个大脑区域的大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 灵长类动物研究研究
背景情况:
- 是一种常见的感官体验,驱动着的冲动.
- 对于感的神经通路是已知的,但控制机制是不清楚的.
研究的目的:
- 为了研究控制抓行为的神经机制.
- 为了确定参与调节引起的伤的脑部区域.
主要方法:
- 利用成像来监测左侧大脑 (LHb) 中的神经活动.
- 研究了外围MrgprD+C纤维附属体和PIEZO2在LHb激活中的作用.
- 研究了LHb激活对 (CQ) 引起的抓行为的影响.
主要成果:
- 左侧的LHb神经元在擦伤结束后显示出增加的活动.
- 左侧LHb的激活以强度依赖的方式抑制引起的.
- 周围的MrgprD+C纤维附加剂和PIEZO2对于擦伤引起的LHb激活和随后的擦伤抑制至关重要.
结论:
- 确定了一条从外围到大脑的新的神经通路,控制引起的.
- 证明左侧大脑管在调节伤行为中起着至关重要的作用.
- 揭示了与体感处理相关的哺乳动物LHb功能中以前未知的左右不对称.
关键词:
LHbb LHbb LHb LHb LHb LHb LHb LHb LHb LHb LHb LHb LHb LHb LHb LHb这是一个NP1的 afferent.这是一个Piezo22.在TRAP的标签上不对称的大脑功能化学遗传学 化学遗传学一个,一个,一个.视觉遗传学 视觉遗传学一个叫做scratch的游戏.更多相关视频
13:04Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings
Published on: May 7, 2016
7.9K
08:01Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
Published on: June 26, 2016
10.5K
相关概念视频
Sensory Functions of the Skin
7.8K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
7.8K
Somatosensation
42.9K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
42.9K
Accessory Structures of the Skin: Hair and Hair Follicles
4.2K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
4.2K
Major Somatic Sensory Pathways
2.3K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.3K
Diencephalon: Anatomical Regions
4.7K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
4.7K
Overview of Somatic Sensory Pathways
8.2K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
8.2K
