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一个基于元分析的不良结局途径,用于动物中和多基物质诱导的生殖毒性

Ying Zhu¹, Chao Zhao¹, Hong Guo²

¹School of Public Health, Yangzhou University, Yangzhou 225000, China.

|November 25, 2025

概括

和多醇基物质 (PFAS) 对繁殖有毒. 这项研究使用了不良结果途径 (AOP) 和元分析来显示PFAS增加反应性氧物种 (ROS),导致动物的繁殖损害.

科学领域:

环境毒理学环境毒理学
生殖毒理学生殖毒理学
机械毒理学机械毒理学

背景情况:

和多醇基物质 (PFAS) 是无处不在的环境污染物,已知具有生殖毒性.
在PFAS引起的生殖毒性背后的精确机制仍然不完全理解.
不利结果途径 (AOPs) 提供了一个框架,将分子启动事件与不利结果联系起来.

研究的目的:

系统地评估已确定的AOP和PFAS诱导的生殖毒性之间的关联.
使用元分析量化PFAS对动物生殖健康终点的影响.
为了阐明PFAS生殖毒性的机制性途径.

主要方法:

利用AOP概念框架来组织和解释毒性数据.
进行了对28项研究的元分析,调查动物模型中PFAS暴露和生殖结果.
在AOP中确定了关键事件 (KE),包括氧化应激,线粒体功能障碍和荷尔蒙干扰.

主要成果:

增加反应性氧物种 (ROS) 被确定为关键分子启动事件 (MIE).
分析显示,在PFAS暴露后,青少年生存率 (SMD: -3.10),男性丸激素 (SMD: -4.17) 和女性雌激素 (SMD: -1.98) 显著降低.
识别了许多细胞KE,包括DNA损伤,内质网膜应激,和改变的激素受体表达,将MIE与生殖功能障碍联系起来.

结论:

暴露于PFAS会触发一连串由ROS启动的细胞事件,导致动物显著的生殖毒性.
该研究提供了对PFAS生殖毒性的机制性理解,支持了AOP框架.
这些发现为环境风险评估和开发更安全的替代品提供了科学基础.

关键词:

负面结果的途径.动物动物动物动物动物进行元分析分析.和多醇基物质 (PFAS) 是一种生殖性毒性生殖性毒性

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