针对肝细胞癌微环境的综合疗法
Shriraam Karunakaran1, Mohan Krishna Ghanta2, Anusha Lakshmi Cheetiyar3
1Department of Biochemistry, MVJ Medical College and Research Hospital, Bangalore, Karnataka 562114, India.
Drug discovery today
|November 25, 2025
概括
新的全身和肝脏导向疗法对转移性肝细胞癌 (HCC) 有希望. 将免疫检查点抑制剂与向药物结合起来,并探索细胞疗法,为改善HCC治疗患者的结果提供了一个新的前沿.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 癌症免疫学 癌症免疫学
- 翻译性瘤学是指翻译性瘤学.
背景情况:
- 肝细胞癌 (HCC) 中的瘤微环境 (TME) 显著影响瘤的进展和对治疗的抗性.
- 了解HCC微环境 (ME) 中免疫和非免疫细胞的复杂相互作用,对于开发有效的治疗方法至关重要.
研究的目的:
- 本综述综合了最近系统疗法的进展,结合了转移性HCC的肝脏导向方法.
- 突出针对HCC微环境的新型治疗策略,并提高免疫疗法的有效性.
主要方法:
- 关于转移性HCC的全身和肝脏导向疗法的当前文献的叙述性综述.
- 对新兴治疗方法的分析,包括免疫检查点抑制剂,小分子剂,表观遗传抑制剂,基于RNA的疗法和细胞疗法 (例如CAR-T细胞).
主要成果:
- 组合疗法 (例如,特梅利马布/杜尔瓦马布与伦瓦提尼布/卡博赞提尼布) 通过增强T细胞激活来证明改善无进展生存率.
- 基因表观和基于RNA的药物显示出调节HCC ME的潜力,以提高免疫治疗的有效性.
- 针对GPC3的细胞疗法 (例如GPC3-CAR-T) 显示出有希望的初步结果.
结论:
- 在ME中HCC免疫亚型的异质性对生物标志物选择和治疗序列提出了挑战.
- 针对特定的HCC微环境量身定制的个性化治疗策略代表了管理高级HCC的未来方向.
相关概念视频
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K


