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咖啡摄入量与严重精神障碍中的端粒长度有关
Vid Mlakar1, Marta Di Forti2,3, Els F Halff2,4
1Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK vid.2.mlakar@kcl.ac.uk.
BMJ mental health
|November 25, 2025
概括
每天喝3-4杯咖啡与严重精神障碍患者的端粒延长有关,这可能表明年轻的生物年龄. 这一发现表明,适度饮用咖啡对细胞衰老有保护作用.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 营养科学 营养科学
背景情况:
- 端粒长度 (TL) 表明细胞衰老;严重的精神障碍与较短的TL相关.
- 咖啡消费可能会减轻氧化应激和生物衰老.
- 咖啡对精神病患者TL的影响尚不清楚.
研究的目的:
- 调查严重精神障碍患者的咖啡消费和端粒长度之间的关联.
主要方法:
- 对436名患有精神分裂症谱或情感障碍的参与者的横截面研究.
- 使用定量实时聚合酶连锁反应 (qPCR) 测量白细胞端粒长度.
- 自我报告的咖啡消费量,每天的杯子.
主要成果:
- 在咖啡摄入量和TL之间观察到一个反转的J形关系,峰值为每天3-4杯.
- 与非饮酒者相比,在建议剂量 (≤4杯/天) 内饮酒的人群中,TL显著更长.
- 适度的咖啡消费 (每天3-4杯) 与与生物年龄相比5岁更小的TL相关,经过调整以考虑混因素.
结论:
- 适度饮用咖啡 (≤4杯/天) 与严重精神障碍患者的端粒时间延长有关.
- 这种关联表明潜在的抗衰老益处,相当于5年更年轻的生物年龄.
- 研究结果支持中度咖啡摄入量在管理精神病患者细胞衰老中的潜在作用.
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