现有的严重精神疾病对癌症死亡率的影响:系统性审查和元分析
Nikoline Riis1, Malene Vestergaard1, Mette Asbjoern Neergaard1,2,3
1Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Acta psychiatrica Scandinavica
|November 25, 2025
概括
患有严重精神障碍 (SMD) 的人患癌症特异性死亡率的风险更高. 这一系统性审查发现相对风险增加了37%,特别是在精神分裂症或精神病患者中.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 患有严重精神障碍 (SMD) 的个人经历了预期寿命的减少.
- 在SMD人群中,癌症特异性死亡率显示了先前研究中不一致的发现.
研究的目的:
- 系统地审查和对先前存在严重精神障碍的成年人癌症特异性死亡率进行元分析.
主要方法:
- 从2003年1月起的PubMed,Embase,Psycinfo和Scopus的综合文献搜索.
- 包括在癌症之前被诊断出SMD的成年癌症患者.
- 随机效应模型元分析,用I平方统计学来评估异质性.
主要成果:
- 从4736个记录中,有25项研究符合资格标准.
- 患有乳腺癌的患者患有癌症特异性死亡率的1.37倍较高的相对风险 (95% CI: 1.30-1.44).
- 精神分裂症和精神病患者的相对癌症死亡风险最高 (1.47;95% CI: 1.33-1.63).
结论:
- 预先存在的严重精神障碍与明显更高的癌症特异性死亡率有关.
- 针对癌症和心理健康的综合护理模式对这一群体至关重要.
- 需要进一步的研究来理解和减轻这些差异.
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