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一种特定于人类的STING宏环可以抑制cGAS-STING诱导的炎症

Jian Zheng¹, Junjie Wu², Hang Yin¹

¹Department of Immunology and Department of Pharmacology, Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.

Annals of the rheumatic diseases

|November 25, 2025

概括

一种新型的宏环,P1,通过阻断其信号传递来抑制干扰素基因 (STING) 的过度活跃刺激器. 纳米粒子形式Nano-P1在临床前模型中有效降低了炎症并改善了生存率,显示了治疗STING相关炎症性疾病的潜力.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
药物发现药物发现药物发现

背景情况:

干扰素基因 (STING) 信号的过度活性刺激驱动炎症性疾病.
向STING提供了一种治疗策略来控制炎症.

研究的目的:

为了识别和描述人类STING (hSTING) 的新型抑制剂.
在炎症的临床前模型中评估宏环抑制剂的治疗潜力.

主要方法:

使用伪天然的宏环平台发现一个宏环 (P1).
在体外细胞测试以评估P1对hSTING转位和下游信号传递的影响.
对P1结合的hSTING进行晶体分析,以阐明结合机制.
在人性化的STING小鼠模型中使用纳米粒子配方P1 (纳米-P1) 的体内研究.

主要成果:

P1与hSTING的循环核酸结合域结合,将其困在一个不活跃的构造中.
P1抑制了STING-ER转位,减少了干扰素β和促炎细胞因子的产生.
在细胞和体内模型中,纳米-P1有效地抑制了炎症,包括Trex1缺乏的小鼠.
纳米-P1治疗改善了与STING驱动的炎症的小鼠的生长和生存,没有观察到毒性.

结论:

宏环P1是一种强大的hSTING抑制剂.
纳米-P1在治疗由过度活跃的STING驱动的炎症状况方面显示出显著的治疗潜力.
纳米-P1的安全概况支持其临床应用的潜力.

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