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相关概念视频

Bacterial Signaling01:30

Bacterial Signaling

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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Antibiotic Selection00:57

Antibiotic Selection

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Overview
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Reporter Genes02:11

Reporter Genes

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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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相关实验视频

Updated: Jan 10, 2026

Bioluminescent Bacterial Imaging In Vivo
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Bioluminescent Bacterial Imaging In Vivo

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通过基因工程细菌进行无线体内传感.

Ahmet Bilir1, Merve Yavuz2, Urartu Ozgur Safak Seker3,4

  • 1Electrical and Electronics Engineering Dept., Bogazici University, Istanbul, Turkey.

Nature communications
|November 25, 2025
PubMed
概括

这项研究介绍了使用工程细胞检测分子的无线植入式传感器. 细菌活动会降低天线的性能,使无线通信无需电池或用于深层组织监测的电路.

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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
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相关实验视频

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科学领域:

  • 生物医学工程 生物医学工程
  • 合成生物学 合成生物学
  • 无线传感器技术 无线传感器技术

背景情况:

  • 在体内持续的分子监测对于诊断和治疗至关重要.
  • 现有的植入式传感器面临着通过生物组织的电源和无线通信的挑战.
  • 合成生物学提供了用于细胞传感的工具,但将其与可靠的无线数据传输集成是复杂的.

研究的目的:

  • 开发一种无电池,无线植入式传感器系统,利用基因工程细胞.
  • 克服生物组织中电磁信号衰减的挑战,以实现体内通信.
  • 建立一种方法,将细胞活动转化为可检测的无线信号,用于分子传感.

主要方法:

  • 利用基因工程Escherichia coli (大肠杆菌) 来感知特定的分子.
  • 利用细胞反应触发被动微波天线的降解.
  • 采用微波反射传播来无线监控天线的状态,表明细胞活动.

主要成果:

  • 在基于单元的传感器和外部接收器之间展示了一个功能性的无线链接.
  • 在人体幻影中,在25毫米的植入深度实现了分子级感应.
  • 在不需要电池或集成电路的情况下,成功地将细胞活动转换为可检测的电磁信号.

结论:

  • 开发的基于细胞的传感器系统提供了一种新的,无电池的方法,用于无线体内分子监测.
  • 这项技术有效地将合成生物学传感与深层组织应用的无线通信相结合.
  • 未来的实施有可能将细菌反应与广泛的分子点合起来,用于各种传感应用.