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Updated: Jan 10, 2026

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
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溶剂诱导的部分细胞固定解码全蛋白质组的药物标和下游途径在活细胞

Ting Yu1,2, Yan Wang1, Keyun Wang1

  • 1State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Nature communications
|November 25, 2025
PubMed
概括

我们开发了一种新的方法,即溶剂诱导部分细胞固定方法 (SICFA),用于研究活细胞中的药物相互作用和蛋白质稳定性. 这种技术提高了检测早期分子事件和药物诱导的途径变化的灵敏度.

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