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Updated: Jan 10, 2026

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国家选择性小分子降解剂,优先去除聚合物和寡合物

Jakub Luptak1,2, Dean Clift1, Aamir Mukadam3

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.

Nature communications
|November 25, 2025
PubMed
概括

研究人员开发了TRIMTACs,这些小分子利用TRIM21 E3酶进行向蛋白质降解. 这些TRIMTACs提供了快速的,特定状态的降解,在抑制聚和治疗病症方面表现优于PROTACs.

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