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Updated: Jan 10, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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发现了一种针对TRKA和RET衍生的coproteins的蛋白质溶解向金氏体

Marialuisa Moccia1, Lingzhi Zhang2, Zhengyu Wang3

  • 1Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia "G. Salvatore" (IEOMI) del CNR, Naples, Italia.

Scientific reports
|November 25, 2025
PubMed
概括

新的蛋白质溶解向化马体 (PROTACs) 有效降解瘤性TRKA和RET蛋白,在细胞系和小鼠模型中显示出强大的抗癌作用. 这凸显了PROTACs作为对抗RET和TRKA驱动癌症的有希望的战略.

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