白物质超强度负担预测整个阿尔茨海默病连续的特定领域的认知衰退
Hamide Nasiri1, Farbod Khosravi2, Parsa Saberian3
1Student Research Committee, School of Medicine, Zanjan University of Medical Science, Zanjan, Iran.
Scientific reports
|November 25, 2025
概括
白质过强度 (WMH) 量与轻度认知障碍 (MCI) 患者的记忆和语言下降有关. 这些发现表明WMH可以作为阿尔茨海默病 (AD) 进展的早期生物标志物.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年学是指老年学的学科.
背景情况:
- 白质过强度 (WMH) 是大脑小血管疾病的标志物,也是阿尔茨海默病 (AD) 认知能力下降的潜在生物标志物.
- 在AD频谱中,WMH在不同认知领域的预测价值尚未完全理解.
研究的目的:
- 在AD连续体中调查WMH体积与记忆,执行功能和语言的认知表现之间的关系.
- 确定WMH体积是否可以作为AD认知衰退的早期预测标志物.
主要方法:
- 来自阿尔茨海默病神经成像计划 (ADNI) 的557名参与者的横截面分析 (认知正常,MCI,AD).
- 使用ADNI-MEM,ADNI-EF和ADNI-LAN复合分数评估的认知功能.
- 使用MRI数据贝叶斯细分量化的WMH体积;使用多重线性回归分析的关联,调整为共变量.
主要成果:
- 从认知上正常到AD群体,WMH体积显示出增加的趋势,但没有统计学意义.
- 在MCI组中,增加WMH体积与较差的记忆 (p=0.045) 和语言 (p=0.045) 评分显著相关.
- 在认知正常或AD痴呆症组中,WMH体积和认知表现之间没有发现显著的关联.
结论:
- 在患有MCI的个体中,WMH体积与记忆和语言衰退特别相关.
- 测量WMH显示了早期生物标志物的潜力,用于识别AD连续性的认知衰退,帮助诊断和治疗.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.执行职能 执行职能 执行职能语言 语言 语言 语言磁共振成像技术 磁共振成像技术记忆 记忆 记忆 记忆 记忆轻度认知障碍 轻度认知障碍白质的超强度是白质的超强度.更多相关视频
07:30Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
3.4K
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
33.7K
相关概念视频
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
01:30Dementia
498
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
498
01:22Alzheimer's Disease: Treatment
772
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
772
01:30Cognitive Development During Adulthood
752
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
752