在手术镇静过程中用雷米马佐拉姆与普罗波相比检测到的呼吸抑制:一个随机试验
Jeayoun Kim1, Seungwon Lee1, Ji Seon Jeong2
1Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
在手术镇静期间,雷米马佐拉姆和普罗波显示出类似的呼吸抑制率. 然而,雷米马佐拉姆提供了更好的血液动力学稳定性,使其成为潜在的低血压患者更安全的选择.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 临界护理医学 临界护理医学
背景情况:
- 程序性镇静通常使用普罗波,但存在关于呼吸抑制的担忧.
- 雷米马佐拉姆是一种超短效的二甲,是一种潜在的替代品,具有有利的安全性.
- 连续图提供了比视觉评估或脉冲氧计更敏感的呼吸监测.
研究的目的:
- 为了比较雷米马佐拉姆和普罗波在使用连续图的过程中对呼吸系统的影响.
- 为了评估这两种麻醉剂之间的呼吸抑制和血液动力学稳定性的发生率.
主要方法:
- 一项前性随机对照试验,涉及70名接受程序镇静的成年患者.
- 患者接受了雷米马佐拉姆或普罗波,两者与雷米芬坦尼尔相结合.
- 连续镜法被用来监测呼吸系统事件,呼吸系统测谎法评估睡眠呼吸暂停的严重程度.
主要成果:
- 呼吸抑制事件的发生频率在雷米马佐拉姆和普罗波组之间是可比的 (中位数[IQR] 2 [1-3]与2 [1-5],p=0.44).
- 两组之间没有观察到睡眠呼吸暂停严重程度的显著差异.
- 与雷米马佐拉姆组相比,普罗波组经历了更频繁的低血压事件和更大的血压降低.
结论:
- 与普罗波相比,雷米马佐拉姆在用图监测时没有显著降低呼吸抑制.
- 雷米马佐拉姆表现出卓越的血液动力稳定性,低血压发作较少.
- 雷米马佐拉姆可能是一个更安全的替代程序镇静在容易低血压的患者.
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