艾兰通过诱导铁和破坏线粒体平衡来抑制肝细胞癌的进展,并破坏线粒体平衡
Kewen Ye1, Zhenghao Zhang1, Shanmei Lv2
1Affiliated Hospital of Shaoxing University, Shaoxing, 312000, China.
Scientific reports
|November 25, 2025
概括
艾兰 (AIL) 通过向HSP90/GPX4通路来抑制肝癌 (HCC),通过铁死诱导细胞死亡. 将AIL与GPX4抑制剂结合起来可以增强其抗癌作用.
科学领域:
- 在瘤学瘤学.
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 艾兰 (Ailanthone,简称AIL) 是一种来自Ailanthus物种的天然化合物,在癌症治疗中表现有前途.
- 在肝细胞癌 (HCC) 中AIL的确切作用机制尚未完全理解.
研究的目的:
- 阐明AIL调节HCC进展的分子机制.
- 研究HSP90/GPX4/ferroptosis轴在AIL抗癌作用中的作用.
主要方法:
- 在体外和体内对HCC细胞增殖和转移的研究.
- 分析AIL与HSP90的相互作用及其对GPX4无处不在和表达的影响.
- 评估HCC细胞中的ferroptosis诱导.
- 对AIL与GPX4抑制剂结合的协同效应的评估.
主要成果:
- 艾滋病药物显著抑制了HCC细胞的增殖和转移.
- AIL与HSP90直接相互作用,促进GPX4的无处不在并降低GPX4水平.
- 在HCC细胞中,AIL诱导了铁亡.
- 结合AIL和GPX4抑制剂显示出协同作用的抗增殖效应.
结论:
- HSP90/GPX4/ferroptosis通路对于AIL的抗HCC活性至关重要.
- AIL代表了HCC的潜在治疗剂,通过诱导铁亡作用.
- 针对HSP90/GPX4轴为HCC治疗提供了一个有希望的策略.
相关概念视频
01:16Necrosis
6.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.3K
01:46Electron Transport Chain: Complex I and II
18.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.4K
01:24Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K