对高级上道泌尿道癌和膀癌的顺序治疗结果
Manato Kanesaka1, Tomokazu Sazuka2,3, Yuki Kita4
1Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
Scientific reports
|November 25, 2025
概括
与膀癌 (BC) 相比,上泌尿道尿癌 (UTUC) 患者面临着更糟糕的预后和更低的化疗反应率. 这凸显了对UTUC进行改善的第一线治疗的需要.
科学领域:
- 在瘤学瘤学.
- 泌尿器细胞癌的癌症.
背景情况:
- 尿路癌 (UC) 可以影响上泌尿道 (UTUC) 或膀 (BC).
- 关于UTUC和BC之间的临床结果和治疗顺序的有限比较数据存在.
研究的目的:
- 为了比较局部晚期/转移性UTUC和BC之间的临床结果和顺序治疗模式.
- 为了确定影响这些患者队伍生存的预后因素.
主要方法:
- 在2020年1月至2021年12月期间诊断出局部晚期/转移性UC (232 UTUC,285 BC) 的517名患者的多中心回顾性分析.
- 倾向性得分匹配用于控制基线差异.
- 使用多变量分析来确定总生存时间 (OS) 的独立风险因素.
主要成果:
- 在UTUC患者中,功能较差,肺/肝转移率较高.
- UTUC是更糟糕的OS和显著更短的无进展生存期 (PFS) 的独立风险因素.
- 第一线化疗反应率在UTUC (28.9%) 比BC (38.2%) 低,在第二线治疗后的生存状况较差,并且无法继续第三线治疗的比例更高 (47.9%在UTUC).
结论:
- 与BC相比,UTUC的预后更差,需要更有效的第一线治疗策略.
- 免疫组合疗法被认为是一种潜在的改善,特别是在同步的UTUC病例中.
- 对UTUC的新型治疗方法的进一步研究至关重要.
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