开发和优化moxifloxacin固体脂质纳米颗粒通过双乳液有机无溶剂技术应用Box-Behnken实验设计
Esraa M Elshazly1, Mona G Arafa2,3,4, Samia A Nour5
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Scientific reports
|November 25, 2025
概括
研究人员使用无溶剂方法开发了含有moxifloxacin的固体脂质纳米颗粒 (SLN),以改善慢性伤口愈合. 优化的SLN显示了增强药物递送和延长释放的潜力,提供了一个新的治疗策略.
科学领域:
- 制药纳米技术 制药纳米技术
- 药物输送系统 药物输送系统
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 慢性伤口在愈合过程中存在重大挑战,原因是药物透性差和持续释放等因素.
- 传统的药物输送系统往往难以在伤口提供有效和长时间的治疗作用.
研究的目的:
- 开发和优化含有moxifloxacin的固体脂质纳米颗粒 (SLNs),以改善慢性伤口愈合.
- 研究配方变量对纳米粒子特性和药物捕获的影响.
- 评估优化SLNs的潜力,以改善皮肤分布和持续的抗生素释放.
主要方法:
- 用于制备SLN的无溶剂双乳液技术.
- 采用Box-Behnken设计,用于对酸,Span 80和Tween 80度进行统计优化.
- 捕获效率 (EE%),泽塔潜力 (ZP) 和粒子大小 (PS) 是关键的优化参数.
- 福利埃变换红外光谱 (FTIR),X射线衍射 (XRD),传输电子显微镜 (TEM) 和扫描电子显微镜 (SEM) 用于表征.
主要成果:
- 优化的SLNs配方实现了高可取性 (0.851),ZP为-52.4mV,EE%为~79.6%,PS为257nm.
- 酸对EE有积极的影响,Span 80增加了PS,Tween 80增强了ZP.
- FTIR和XRD证实了化学兼容性和成功封装,降低了药物的晶度.
- 通过TEM和SEM成像,证明了具有光滑表面的球形纳米粒子.
结论:
- 通过无溶剂方法制备的优化莫西弗洛克萨辛载荷的SLN显示了用于伤口愈合应用的有希望的特性.
- 预计纳米颗粒配方将改善皮肤透,并提供持续释放的莫西素.
- 这种方法为治疗慢性伤口提供了一个潜在的有效的治疗策略.
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