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Updated: Jan 10, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

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哈什综合体促进了多能性的退出

Bowen Wang1, Min Qi1, Yanqi Sun1

  • 1State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, China.

Communications biology
|November 25, 2025
PubMed
概括

人类沉默枢纽 (HUSH) 综合体对于保持基因组完整性至关重要. 研究了它在维持多能性的作用,揭示了HUSH核心成员MPP8和TASOR通过细胞粘附基因调节从多能性退出.

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