老年人营养风险指数和C-反应蛋白:跨导管大动脉植入的预后影响
Kayo Sugiyama1, Masanobu Fujimoto2, Wataru Suzuki2
1Department of Cardiac Surgery, Aichi Medical University Hospital, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. kayotaro3@gmail.com.
Heart and vessels
|November 25, 2025
概括
低老年营养风险指数 (GNRI) 显示的营养不良和高C反应蛋白 (CRP) 显示的炎症预测了经过跨导管大动脉植入 (TAVI) 的患者的长期死亡率. 这种综合风险因素对于TAVI患者的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 通过导管大动脉植入 (TAVI) 患者的炎症和营养标志物的预后意义正在争论中.
- 老年营养风险指数 (GNRI) 和C反应蛋白 (CRP) 分别是营养状况和炎症的关键指标.
研究的目的:
- 调查GNRI和CRP对死亡率和主要脑/心血管不良事件 (MACCE) 的预后影响,在接受选择性TAVI治疗大动脉狭窄症 (AS) 的患者中.
主要方法:
- 分析了2017年4月至2023年5月期间接受AS选择性TAVI治疗的122名患者的队列.
- 主要结局是全因死亡率;次要结局包括MACCEs.
- 进行了单变量和多变量分析,以评估GNRI和CRP与结果的关联.
主要成果:
- 低GNRI,高CRP及其组合与明显更高的全因死亡率有关.
- 虽然GNRI和CRP单独显示了与晚期死亡率的单变体关联,但在多变体分析中,只有低GNRI和高CRP的组合仍然具有意义.
- 低GNRI在TAVI后持续存在,并且与晚期死亡率或MACCEs无关.
结论:
- 营养不良 (低GNRI) 和炎症 (高CRP) 的组合是AS接受TAVI治疗的患者长期死亡的重要风险因素.
- 这些综合指数为TAVI患者管理提供了有价值的预后信息.
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