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辅酶Q10对大鼠的环胺诱导的卵巢损伤的保护作用
Mehmet Yildiz1, Volkan Kosal2, Omer Faruk Keles3
1Department of Obstetrics and Gynecology Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, Turkey. mehmetyildiz@yyu.edu.tr.
Scientific reports
|November 25, 2025
概括
辅酶Q10 (CoQ10) 通过增强抗氧化酶和减少组织损伤,部分保护大鼠免受化疗诱导的卵巢损伤. 需要进一步的研究来证实其对生育能力的长期影响.
科学领域:
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 化疗,特别是循环胺 (CP),可以引起显著的卵巢毒性.
- 氧化应激在化疗引起的卵巢损伤中起着关键作用.
- 辅酶Q10 (CoQ10) 是一种强大的抗氧化剂,具有潜在的保护性.
研究的目的:
- 为了研究辅酶Q10对CP诱导的卵巢损伤在雌性Wistar大鼠的保护作用.
- 评估卵巢组织中的生化,遗传和组织病理变化.
- 评估CoQ10作为治疗药物对化疗诱导的卵巢毒性的潜力.
主要方法:
- 鼠被分为五组:对照组,假型组,CP组,CoQ10组和CP+CoQ10.
- CP和CoQ10被口服四周时间.
- 生物化学测定测量了抗氧化酶活性 (CAT,SOD,GPx).
- 通过RT-qPCR分析了亡基因表达 (caspase-3, -8, -9).
- 组织病理学检查评估了卵巢组织损伤.
主要成果:
- 辅酶Q10的使用显著增加了卵巢组织中的催化酶 (CAT) 和超氧化失调酶 (SOD) 水平.
- 组织病理学分析显示,与CP组相比,CP+CoQ10组的结构损伤减少.
- 两组之间没有观察到谷氨过氧化酶 (GPx) 活性或酶基因表达的显著差异.
结论:
- 在老鼠中,CoQ10表现出部分保护性作用,防止循环胺诱导的卵巢氧化应激和组织学损伤.
- 观察到的好处与增强的抗氧化酶活性有关.
- CoQ10对亡基因表达的影响是有限的,需要进一步的研究来确定其长期疗效和对生育结果的影响.
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