2岁时生长与神经发育之间的关联在中度和晚期的早产期中
Anne H Lafeber1, Mark Bosch1, Cornelieke S H Aarnoudse-Moens2
1North West Clinics, Department of Pediatrics and Neonatology, Alkmaar, The Netherlands.
Pediatric research
|November 25, 2025
概括
在住院期间,中度和晚期早产婴儿 (MLPTI) 的生长显示出更好的神经发育结果的趋势. 然而,前两年的整体增长与修正年龄的认知或语言成绩没有显著的相关性.
科学领域:
- 新生儿科学 新生儿科学
- 发育儿科 发育儿科
- 儿科神经学 儿科神经学
背景情况:
- 中度和晚期早产婴儿 (MLPTI,32 0/736 6/7周怀孕) 容易出现生长缺陷和神经发育延迟.
- 对于长期的神经发育结果,对MLPTI的早期生长模式尚不清楚.
研究的目的:
- 在MLPTI中调查婴儿生长和神经发育结果在2岁时的纠正年龄 (CA) 之间的联系.
- 为了确定医院内生长或医院后生长是否对神经发育有不同的影响.
主要方法:
- 在100个MLPTI中,从出生到2岁的CA中收集人类学数据的前景收集.
- 使用贝利婴幼儿发展尺度进行神经发育评估,第三版 (BSID-III-NL).
- 用多变量回归分析来分析数据.
主要成果:
- 在2年CA时,在住院长度增长 (Δz-score) 和认知得分 (p=0.025) 和语言得分 (p=0.041) 之间观察到正相关性.
- 一个不显著的趋势表明,增加的住院体重增加 (Δz-分数) 与更高的认知分数相关 (p=0.097).
- 在医院出院后的生长和2年CA后的神经发育结果之间没有发现显著的关联.
结论:
- 早期的住院生长,特别是长度,可能会对MLPTI的神经发育结果产生积极的影响.
- 到2年后的医院后生长CA没有显示与神经发育结果的显著关联.
- 需要进一步的研究来阐明影响这种脆弱的早产人口生长和神经发育的因素.
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