生物标志物测试和针对性治疗在NSCLC中的教育和公平影响:来自NIH我们所有人的研究计划的见解
Patrick J Kiel1, Todd C Skaar2, David R Foster1
1College of Pharmacy, Purdue University, West Lafayette, IN, USA.
概括
非小细胞肺癌 (NSCLC) 的精确瘤学需要生物标志物测试. 教育差距和教育水平等社会因素影响了获得向治疗的机会,突出了护理方面的差异.
科学领域:
- 在瘤学瘤学.
- 健康差异 在健康上的差异
- 基因组学就是基因组学.
背景情况:
- 非小细胞肺癌 (NSCLC) 的精确瘤学依赖于生物标志物测试来选择向治疗.
- 在生物标志物测试和有针对性的治疗准入方面存在显著差异,这表明患者,提供者和卫生系统层面之间存在关键的教育需求.
研究的目的:
- 调查健康的社会决定因素 (SDoH) 与生物标志物测试和高级NSCLC患者接受向治疗之间的关联.
- 确定面临精确瘤护理障碍的患者子组.
主要方法:
- 利用NIH我们所有人研究计划 (2017-2022) 对287名接受一线治疗的晚期NSCLC患者的数据.
- 评估了包括教育,就业,退休和残疾在内的SDoH因素,作为生物标志物测试和向治疗的预测因素.
- 分析了几率比率 (OR) 和95%置信区间 (CI) 以评估统计学意义.
主要成果:
- 只有18%的患者记录了生物标志物测试,尽管45%的少数民族代表.
- 有大学教育的患者接受向治疗的几率更高 (OR 2.43).
- 退休患者接受向治疗的可能性较低 (OR 0.35),而残疾与增加的生物标志物测试有关 (OR 2.82).
结论:
- 调查结果揭示了生物标志物测试和受SDoH影响的向治疗访问的显著差异.
- 加强患者和提供者教育对于提高生物标记素养,遵守指南和公平的NSCLC精确瘤学至关重要.
- 针对退休人员和教育程度较低的个人进行有针对性的宣传,以及系统层面的改进,是解决护理差距的必要条件.
相关概念视频
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...


