Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Families02:47

Protein Families

16.6K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
16.6K
Protein Organization01:24

Protein Organization

9.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
9.0K
Protein Organization01:13

Protein Organization

155.6K
Overview
155.6K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

46.7K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
46.7K
Protein Folding01:25

Protein Folding

11.0K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.0K
Protein Folding01:22

Protein Folding

125.9K
Overview
125.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Performability evaluation, validation and optimization for the steam generation system of a coal-fired thermal power plant.

MethodsX·2022
Same author

A Comparative Study of Blood Loss With and Without Infusion of Tranexamic Acid in Total Knee Replacement.

Cureus·2022
Same author

Reply to Oren et al., "New Phylum Names Harmonize Prokaryotic Nomenclature".

mBio·2022
Same author

Ecological variations in adult life table attributes of Aedes aegypti (L.) from the desert and coastal regions of India.

Medical and veterinary entomology·2022
Same author

Registration of polarimetric images for in vivo skin diagnostics.

Journal of biomedical optics·2022
Same author

High interfacial charge separation in visible-light active Z- scheme g-C<sub>3</sub>N<sub>4</sub>/MoS<sub>2</sub> heterojunction: Mechanism and degradation of sulfasalazine.

Chemosphere·2022

相关实验视频

Updated: Jan 10, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K

AlphaFold数据库结构提取器:一个Web服务器和API,可以使用常见的蛋白质接入来下载AlphaFold结构.

Niharika Saraf1, Vishvesh Karthik1, Gaurav Sharma2

  • 1Microbial Genomics and Evolution Lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India.

BMC bioinformatics
|November 26, 2025
PubMed
概括

AlphaFoldDB结构提取器工具简化了从AlphaFold数据库下载预测的蛋白质结构. 它支持各种标识符和格式,为研究人员提供高效的批量下载.

关键词:
这是一个API工具包API工具包.在AlphaFoldDB中,使用的是AlphaFoldDB.生物信息学是一种生物信息学.计算生物学是一种计算生物学.美国国家银行 (NCBI)开放式访问 开放式访问蛋白质结构 蛋白质结构结构基因组学 结构基因组学这就是UniProt的特点.

更多相关视频

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

909

相关实验视频

Last Updated: Jan 10, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

909

科学领域:

  • 结构生物学 结构生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • AlphaFold数据库包含许多预测的蛋白质结构,但大量访问它们可能具有挑战性.
  • 现有的方法通常对可以访问的结构或模型生物的数量有局限性.

研究的目的:

  • 开发一个开放式访问的Web服务器和API工具包,以便从AlphaFold数据库中高效地批量下载蛋白质结构.
  • 克服超出有限的模型生物和值数量的结构访问的限制.

主要方法:

  • AlphaFoldDB结构提取器接受各种输入标识符,如NCBI分类ID,RefSeq,位置标签和UniProt/AlphaFold加入.
  • 它提供PDB,mmCIF,bCIF或PAE JSON格式的结构文件,并包括ID映射实用程序.
  • 一个API方法可用于程序访问和集成到生物信息学管道.

主要成果:

  • 该工具成功地从AlphaFold数据库中大量下载预测的蛋白质结构.
  • 它支持各种输入标识符和输出格式,包括PDB,mmCIF,bCIF和PAE JSON.
  • 创建一个ID映射文件来追踪输入标识符,并单独报告未映射的ID.

结论:

  • AlphaFoldDB结构提取器简化了从AlphaFold数据库中采购蛋白质结构.
  • 它通过简化数据访问以最小的计算专业知识来赋予结构性和功能性基因组学研究人员权力.