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Updated: Jan 10, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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提高耐药结核病治疗试验的效率:用于细菌学反应的时间对事件替代标记物和随机化适应性最小化

Elise De Vos1,2, Annelies Van Rie3, Steven Abrams3,4

  • 1Department of Family Medicine and Population Health, University of Antwerp, Antwerp, Belgium. elise.de.vos@live.be.

BMC medical research methodology
|November 26, 2025
PubMed
概括

测量真菌细菌负载变化的新模型显著减少了对Rifampicin耐药结核病 (RR-TB) 试验的样本大小. 这种方法与最小化相结合,提高了临床试验的效率.

关键词:
临床试验,第三期临床试验.流行病学方法 流行病学方法随机分配,流行病学研究设计.样本的大小 样本大小结核病,多种药物耐药性

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