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用两种SNP阵列密度对各种马品种的ROH模式和基因组杂交进行细度评估
Moslem Moghbeli Damane1, Ahmad Ayatollahi Mehrgardi2, Ali Esmailizadeh3
1Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran. m.moghbeli@agr.uk.ac.ir.
BMC veterinary research
|November 26, 2025
概括
马匹的基因组内生育被评估使用 homozygosity (ROH) 的运行. 在染色体ECA7和ECA11上确定了ROH岛屿,表明选择事件影响了色素和生育能力等特征.
科学领域:
- 动物遗传学动物遗传学
- 基因组学就是基因组学.
- 人口遗传学 人口遗传学
背景情况:
- 亲生繁殖,亲属之间的交配,降低了马的健康状况,通常是由于地理隔离或选择性繁殖.
- 准确的杂交评估对于管理马的遗传多样性和减轻负面影响至关重要.
- 运行同胞性 (ROH) 分析是一种精确的方法来评估基因组内生育和自胞性.
研究的目的:
- 分析ROH分布并估计14种不同的马品种的基因组内生系数.
- 绘制ROH岛屿的地图,并确定可能受选择影响的基因组区域.
- 了解近亲繁殖对马种群遗传多样性和特征的影响.
主要方法:
- 使用SNP数组数据集 (670K和MNEc2M) 来自424匹和438匹马,分别.
- 分析了279,040个SNP (670K) 和1,083,942个SNP (MNEc2M),以检测同胞性 (ROH) 的运行.
- 估计的基因组杂交系数 (FROH) 和14个马品种的ROH岛屿.
主要成果:
- 大多数检测到的ROH都小于16Mb,平均每个人ROH为81.36 ± 33.38 (670K) 和38.71 ± 22.73 (MNEc2M).
- 平均ROH长度各不相同:每个人248.57Mb (670K) 和89.56Mb (MNEc2M).
- 基因组内生 (FROH) 估计范围从0.0364 ± 0.0049到0.2357 ± 0.0584 (670K) 和0.004 ± 0.0044到0.1102 ± 0.0779 (MNEc2M).
结论:
- 在染色体ECA7和ECA11上确定了显著的ROH岛屿,表明最近的选择事件.
- 这些ROH岛屿含有与重要的马特征相关的基因,如色素,生育能力和表现.
- 罗岛作为有价值的基因组标记,用于了解过去的选择和未来对马的遗传研究.
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