多学科的管理和分子特征的下腔静脉雷奥肌肉瘤:一个案例报告
Alessia Pini1,2, Maria Abbondanza Pantaleo3,4, Annalisa Astolfi3,5
1Vascular Surgery Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy. alessia.pini3@unibo.it.
World journal of surgical oncology
|November 26, 2025
概括
本案例研究突出了一个罕见的下腔静脉 (IVC) 线性肌肉肉瘤. 个性化治疗,包括手术和分子分析,对于管理这种侵袭性癌症至关重要.
科学领域:
- 在瘤学瘤学.
- 血管外科 血管外科
- 遗传学 遗传学 是一个
背景情况:
- 下腔静脉 (IVC) 线性肌肉瘤是一种罕见的,具有不良预后的侵袭性恶性瘤.
- 对于IVC乳腺肌肉肉瘤,没有确立的治疗方案.
- 本报告详细介绍了一个复杂的病例,需要多学科的外科和瘤治疗方法.
研究的目的:
- 为了呈现下腔静脉 (IVC) 线性肌肉肉瘤的病例.
- 讨论管理策略,包括化疗和手术切除.
- 强调分子分析在指导个性化治疗中的作用.
主要方法:
- 一名69岁的男性患者患有IVC乳腺肌肉瘤,接受了用多克索鲁比进行的新辅助化疗.
- 手术切除是由一个多学科的团队进行的,涉及瘤与IVC和右脏的块状切除.
- 下一代测序 (NGS) 用于瘤的分子概况.
主要成果:
- 患者能很好地忍受化疗和手术,无需进行IVC重建.
- 组织病理学证实了从阴道静脉延伸到静脉的乳腺神经肉瘤.
- 在其他方面,NGS在TP53,RB1,KMT2C和TSC2中发现了突变.
- 四个月后发生了局部复发,通过进一步的化疗进行管理.
结论:
- 个性化治疗策略,整合手术决策,化疗和分子表征,对于管理IVC乳腺肌肉瘤至关重要.
- 多学科的合作对于最佳的患者结果至关重要.
- 需要对瘤致癌点进行进一步的研究,以改善这种罕见瘤的预后.
相关概念视频
Varicose Veins II: Diagnostic Studies and Interprofessional Care
169
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
169
Esophageal Varices-II: Clinical Features and Management
349
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
349


