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多omics分析揭示了女性IBS患者的临床-肠-大脑相互作用,这些患者在童年时经历了不良经历

Michelle Binod^1,2,3,4, Lin Chang^5,6,7,8,9, Ming Wei Hung^5,6,7,8,9

¹Division of Pediatric Gastroenterology, Hepatology and Nutrition, UCLA, Los Angeles, CA, USA. MBinod@mednet.ucla.edu.

Biology of sex differences

|November 26, 2025

概括

刺激性肠综合征 (IBS) 的女性的不良童年经历 (ACE) 与明显的肠道细菌和大脑网络改变有关. 这项研究在高ACE女性中确定了IBS的多原子特征,提供了潜在的治疗点.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
微生物组研究微生物组研究

背景情况:

大脑肠道系统促进双向通信,这对于应激反应至关重要.
刺激性肠综合征 (IBS) 是一种影响女性的压力敏感性疾病,与肠-大脑功能障碍有关.
儿童不良经历 (ACE) 通过放大压力反应,加剧IBS风险和严重程度.

研究的目的:

为了确定连接ACE暴露与女性IBS的多原子特征.
为了比较临床,神经成像和肠道微生物群特征在IBS女性高ACE和没有高ACE,与健康的对照 (HC).

主要方法:

分析了来自罗马阳性IBS患者和HC患者的数据,根据IBS诊断和ACE得分 (高ACE≥2,低ACE0-1) 将其分为四个子组.
通过转基因组学评估临床变量,多式脑 MRI 和肠道微生物功能.
使用 eXtreme梯度提升 (XGBoost) 进行特征识别和连接图进行多原子数据可视化.

主要成果:

高ACE的IBS女性报告说,与HC同行相比,抑郁症,焦虑,胃肠道症状焦虑,感知压力和体征症状增加.
在高ACE的IBS女性中,发现了有益细菌 (Akkermansia,Bifidobacterium) 和症状严重程度/ACE相关因素之间的负相关性.
一个组合模型准确地区分了高ACEIBS患者 (AUC=0.87,准确率=78%).

结论:

研究结果揭示了独特的微生物群和大脑网络,这些网络有助于早期生活压力女性的IBS病理生理学.
突出了慢性压力,脑肠微生物系统和IBS之间的复杂相互作用.
确定潜在的治疗目标,以减轻女性IBS患者早期生活压力的长期影响.

关键词:

在阿克克曼斯的阿克克曼西亚.这种细菌是Bifidobacterium.不良的童年经历儿童的不良经历大脑-肠-微生物组系统刺激性肠综合征是什么意思多个omics的多个omics.Salience 网络是一个突出网络.性差异性差异性差异性差异性差异性差异性差异性压力压力压力压力

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