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频率,患者特征和用多塞塔克塞尔扩散的临床管理:使用日本大型医疗索赔数据库进行描述性研究

Rina Yanagisawa¹, Ryo Inose², Yuichi Muraki¹

¹Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi-Cho, Yamashina-Ku, Kyoto, 607-8414, Japan.

Journal of pharmaceutical health care and sciences

|November 26, 2025

概括

在癌症患者中,多西素扩散 (EV) 发生在0.075%的病例中. 包括类固醇使用和专家咨询在内的EV的管理,尽管有指导方针,但仍然很低.

科学领域:

在瘤学瘤学.
药物监督药物监督药物监督
临床药房临床药房

背景情况:

化学疗法引起的外流 (EV) 可能会导致严重的组织损伤.
最近的日本指导方针 (2022年12月) 建议对癌症药物EV进行特定的管理.
在日本,关于EV频率和患者特征的有限大规模数据存在.

研究的目的:

为了调查与多塞 (DTX) 相关的EV的频率和患者特征.
评估DTX相关EV的现实管理,包括类固醇使用和专家咨询.
建立一个基准来评估未来的准则合规性.

主要方法:

一个大型的日本医疗索赔数据库 (2008-2020) 的回顾性分析.
包括接受DTX单一治疗的癌症患者.
对患者人口统计,EV发病率,类固醇处方和专家咨询进行描述性调查.

主要成果:

与DTX相关的EV发生在0.075% (35/46,698) 的患者中.
与普通人群相比,经历了EV的患者中,具有EV史的比例更高 (8.6%).
只有34.3%的人接受了类固醇,11.4%的人咨询了皮肤病学/整形外科.

结论:

DTX单疗与EV发病率较低 (0.075%) 相关.
历史的EV是复发的风险因素.
目前与DTX相关的EV的管理,包括类固醇使用和专家转诊,未得到充分利用,这凸显了遵守指南的差距.

关键词:

数据库数据库数据库是一个数据库.多塞塔克塞尔 (Docetaxel) 是一种这是一种extravasation.日本日本日本日本日本.这是一种类固醇.

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