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Updated: Jan 10, 2026

Experimental Human Pneumococcal Carriage

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

在2022-2023年,美国西南部的土著儿童中携带肺炎球菌

Catherine G Sutcliffe¹, Victoria M Sergent¹, Taj Azarian²

¹From the Center for Indigenous Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

The Pediatric infectious disease journal

|November 26, 2025

概括

西南土著儿童肺炎球菌携带者在流行后减少. 高价值疫苗,如PCV15和PCV20,覆盖了许多血清型,有可能减少这种脆弱人群的携带和疾病.

科学领域:

儿童传染病儿童传染病
微生物学微生物学
疫苗学疫苗学疫苗学

背景情况:

西南地区的土著儿童面临着高重的肺炎球菌疾病负担.
之前的研究显示,2015-2017年肺炎球菌携带率高 (49.5%).
流行病相关的变化和新疫苗可能影响了携带流行率和血清型分布.

研究的目的:

估计西南地区5岁以下儿童中肺炎球菌携带者的目前患病率.
为了确定该群体中Streptococcus pneumoniae的血清型分布.

主要方法:

一项横截面研究在2022-2023年招收了7-59个月的土著儿童.
使用培养和PCR进行分析,以检测Streptococcus pneumoniae.
使用培养分离物的全基因组测序进行了血清定型.

主要成果:

在67.9%的儿童中检测到肺炎球菌 (40.8%通过培养,67.5%通过PCR).
更高的患病率与家庭中6岁以下的儿童和喘相关.
按文化区分的运输普及率 (40.8%) 低于2015-2017年 (49.5%).
血清型检测显示了19.6%的PCV15型和39.2%的PCV20型血清型.

结论:

与流行前水平相比,肺炎球菌培养载体的流行率有所下降.
携带的血清型中很大一部分是由较新的,高价值的疫苗 (PCV15,PCV20) 覆盖的.
这些疫苗有望减少原住民儿童的肺炎球菌携带和疾病.

关键词:

土著人的健康状况.儿科儿科儿科儿科肺炎球菌的运输车辆肺炎球菌疫苗的使用.

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