关于慢性伤口感染和当前治疗方法的全面概述
Sarah Fakher1, David Westenberg1
1Department of Biological Sciences, Missouri University of Science and Technology, Rolla, Missouri, USA.
概括
慢性伤口感染涉及生物膜和耐药性,延迟愈合. 使用生物材料,纳米技术和药物输送系统的新抗微生物策略提供了更好的感染管理和组织再生,以便更好地护理伤口.
科学领域:
- 生物医学工程 生物医学工程
- 传染性疾病 传染性疾病
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 由于生物膜,抗生素耐药性和延迟愈合,慢性伤口感染带来了重大的临床挑战.
- 这些情况涉及长时间的炎症,微生物殖民和受损的组织再生,增加发病率和医疗保健费用.
- 了解病理生理学和生物膜形成对于开发有效的治疗方法至关重要.
研究的目的:
- 审查当前关于慢性伤口类型和病理生理学的知识.
- 检查慢性伤口感染管理的抗微生物策略的进展.
- 探索生物材料和创新技术在增强伤口愈合和感染控制方面的作用.
主要方法:
- 关于慢性伤口类型,病理生理学和生物膜机制的文献综述.
- 分析当前和新兴的基于抗微生物的策略.
- 评估创新技术,如纳米技术,先进的药物输送和生物活性成分.
- 评估生物材料在伤口微环境调制中的应用.
主要成果:
- 各种材料和技术的设计旨在改善感染管理和组织再生.
- 创新包括纳米技术,先进的药物输送系统和生物活性成分.
- 生物材料可以量身定制,通过与伤口微环境相互作用来减轻感染风险并加速愈合.
结论:
- 新兴的策略显示,通过整合感染生物学,生物膜动态和生物材料干预,对慢性伤口护理具有前途.
- 需要一个统一的框架,结合感染控制,诊断挑战和基于生物材料的方法.
- 跨学科和多层次的治疗策略对于慢性伤口管理的未来至关重要.
相关概念视频
Phases of Wound Repair
7.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.8K
Healthcare Associated Infections II: Preventive Measures
3.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.6K
Endocarditis IV: Nursing Management
305
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
305
Endocarditis III: Medical Management
200
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
200
Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Venous Thrombosis III: Interprofessional Care
268
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
268


