在 Wada 试验中,大麻使用者的埃托米达剂量和恢复:回顾性队列研究
Jason Chui1,2,3, Abdulaziz Alsaaran1, Susan Hayman-Abello3,4
1Department of Anesthesia and Perioperative Medicine, University of Western Ontario and London Health Science Centre, London, Ontario, Canada.
Journal of neurosurgical anesthesiology
|November 26, 2025
概括
大麻使用需要在半球麻醉的 Wada 测试期间更高的 etomidate 剂量. 使用大麻的患者在麻醉注射后恢复时间也更快.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在Wada测试中,用于术前语言和记忆侧面化,Wada测试使用了内酸乙酸盐.
- 有限的证据存在于影响内卡洛伊托米达剂量的因素.
- 这项研究调查了大麻使用对埃托米达剂量的影响.
研究的目的:
- 为了确定大麻使用是否会影响Wada测试期间的内卡罗蒂德乙胺剂量.
- 探索其他影响埃托米达剂量的因素,如体重.
- 为了比较大麻使用者和非使用者之间的恢复药学动力学.
主要方法:
- 对接受Wada测试的成年患者的回顾性分析 (2012年2月至2024年1月).
- 主要暴露:积极使用大麻. 主要结局:总的埃托米达剂量 (mg).
- 进行了多变量线性回归和药理动力学比较.
主要成果:
- 活跃的大麻使用与明显更高的埃托米达总剂量相关 (调整后β=0.99,P=0.04).
- 年龄,性别,体重和药物滥用史没有显著影响etomidate剂量.
- 大麻使用者在注射后表现出更快的运动力恢复 (更短的时间,P=0.01).
结论:
- 在Wada测试中,大麻使用与增加的埃托米达剂量要求有关.
- 大麻使用者在服用埃托米达后表现出加速恢复时间.
- 调查结果表明,在接受Wada测试的大麻使用患者中,可能需要调整埃托米达的剂量.
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