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微观性结肠炎与瑞典人口中痴呆的风险增加有关
Xiaoying Kang1,2,3, David Bergman1, Jiangwei Sun1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
显微性结肠炎 (MC) 患者在病后五年内出现痴呆症诊断的风险更高. 然而,MC患者患有先前存在的痴呆症的患病率较低,这表明可能的诊断不足.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 肠-大脑轴与痴呆症有关.
- 微观性结肠炎 (MC) 是一种与年龄相关的炎症性肠病,与肠道失生症有关.
- 目前尚不清楚MC和痴呆症之间的关系.
研究的目的:
- 为了调查微观结肠炎和痴呆症之间的关联.
- 探索MC诊断和痴呆发病率之间的时间关系.
- 检查MC患者中先前存在的痴呆症的患病率.
主要方法:
- 使用了瑞典 (ESPRESSO) 的全国性队列研究,包括MC患者和基于人口的比较者和兄弟姐妹.
- 采用匹配的队列和病例控制设计,分别评估发病和流行痴呆症.
- 数据涵盖了30岁及以上患者的1990-2017年的诊断.
主要成果:
- 在诊断后5年内,MC患者的痴呆风险增加了19% (aHR: 1.19),包括阿尔茨海默病和血管痴呆症.
- 与兄弟姐妹相比,这种短期风险升高更为明显 (aHR: 1.55).
- 5年后,这种关联减弱到无效. 在MC患者中,先前存在的痴呆症较少发生 (aOR:0.73),这种关联在兄弟姐妹的比较中没有观察到.
结论:
- 显微性结肠炎患者在疾病过程的早期可能面临痴呆症诊断的高风险.
- 脑膜炎和先前存在的痴呆症之间的反向关联表明,在痴呆症患者中,脑膜炎的潜在诊断不足.
- 需要进一步的研究来探索MC对痴呆风险和诊断的影响.
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