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鉴定具有抗阿尔法病毒活性的spirodioxolane nsP2螺旋酶抑制剂

Hans J Oh1,2, John D Sears2,3, Bose Muthu Ramalingam1,2

  • 1Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA tim.willson@unc.edu.

RSC medicinal chemistry
|November 26, 2025
PubMed
概括

新的螺旋二醇化合物有效抑制阿尔法病毒nsP2化酶 (nsP2hel). 这些直接作用的抗病毒药物表现出广泛的活性,并克服了老药物所见的抗药性.

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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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