前生物可信可以自组装成富含β的纳米结构
Mikhail Makarov1, Robin Kryštůfek2,3, Matúš Friček1
1Department of Cell Biology, Faculty of Science, Charles University, Prague, 12800, Czech Republic.
bioRxiv : the preprint server for biology
|November 26, 2025
概括
早期的地球,丰富的酸性氨基酸,容易形成可溶性,自组合的聚合物. 这些未进化的序列显示了在核糖体进化之前的前生物催化和类似蛋白质的结构的潜力.
科学领域:
- 生命的起源 研究 研究 研究
- 生物化学 生物化学
- 天体生物学 天体生物学
背景情况:
- 预生物地球可能缺乏丰富的基本氨基酸 (lysine, arginine,histidine).
- 在核糖体合成之前,早期的是短的,统计的,并且没有模板.
- 了解早期蛋白质和酶的出现对于生命起源研究至关重要.
研究的目的:
- 调查随机图书馆的特性,使用一个前生物学上可信的酸性氨基酸字母表.
- 确定这些序列是否可以形成与早期蛋白质进化相关的结构.
- 探索预微生物中自我组装,二次结构和催化活性的潜力.
主要方法:
- 跨越静电光谱的随机库的合成.
- 系统地调查的特性,包括二次结构和组合.
- 对金属离子结合能力的分析.
- 使用大型语言模型进行结构预测.
主要成果:
- 富含酸性氨基酸的对二次结构 (β-片) 和可溶性,高阶组件具有强烈的倾向.
- 这些组合是异质的,与统计早期地球相一致,与粉样结构不同.
- 酸性具有固有的金属离子结合能力,表明具有催化潜力.
- 大型语言模型的预测表明,这些酸性的紧形状倾向于紧.
结论:
- 预微生物可用的酸性氨基酸的未演化序列可以很容易地形成可折叠的,自组合的聚合物.
- 这些发现表明,在基因选择出现之前,可能是第一批蛋白质的脚石.
- 酸性的固有特性为生命起源的关键问题提供了可信的解决方案.
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