局部和网络神经激活及其与睡眠参数的关联在威胁调节和灭绝期间,在有或没有失眠障碍的人群中具有通用焦虑症
Jeehye Seo1, Cagri Yuksel2,3, Katelyn I Oliver4
1Department of Radiology and Advanced Medical Imaging Institute and Anam Hospital, Korea University College of Medicine, Seoul, KR.
bioRxiv : the preprint server for biology
|November 26, 2025
概括
通用焦虑障碍 (GAD) 与失眠障碍 (ID) 显示了威胁灭绝学习的神经活动受损,随着更好的睡眠质量而改善. 在GAD中睡眠障碍可能会阻碍焦虑减轻机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 缺陷的灭绝学习与病态焦虑和睡眠障碍有关.
- 泛性焦虑症 (GAD) 经常与失眠症 (ID) 一起发生.
研究的目的:
- 调查中度至重度ID患者和没有中度至重度ID患者之间威胁条件和灭绝学习中的神经激活差异.
- 探索睡眠质量与这些过程中的神经活动之间的关系.
主要方法:
- fMRI用于测量GAD患者在威胁调节,灭绝学习和回忆期间的神经激活.
- 参与者被分为GAD与中度至重度的ID (GAD+ID) 和GAD与缺席/下值ID (GAD-ID) 组.
- 分析将大脑激活与睡眠质量和生理测量相关联.
主要成果:
- 与GAD-ID相比,GAD+ID组在威胁调节期间表现出更广泛的神经激活.
- 灭绝学习激活在GAD-ID中比GAD+ID更大,并且在后者中被延迟.
- 更高的睡眠效率与威胁条件激活的减少相关,但增加了灭绝学习激活.
结论:
- 更好的睡眠质量增强了神经基质的参与,这对GAD的灭绝学习至关重要.
- 患有ID的GAD患者在立即灭绝学习方面表现出缺陷,这可能会通过延迟暴露来补偿.
- 睡眠障碍可能会阻碍神经机制 GAD 焦虑减轻的基础.
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