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Updated: Jan 10, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

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替代分离和全球转录组变化与人类外周血液单核细胞中的LPS刺激相关

Esther Chavez-Iglesias, Anatol Sucher, Nidhi Thati

    bioRxiv : the preprint server for biology
    |November 26, 2025
    PubMed
    概括

    脂聚糖 (LPS) 触发免疫反应,这项研究显示,替代拼接 (AS) 显著影响炎症途径. 关键免疫基因和非编码RNA中的AS为免疫疾病提供了潜在的治疗点.

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    相关概念视频

    RNA Splicing01:32

    RNA Splicing

    Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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    Alternative RNA Splicing02:18

    Alternative RNA Splicing

    Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
    There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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