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Updated: Jan 10, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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UCM-A86是一种GluN1/GluN3 NMDA受体的选择性阳性全调节器

Avery J Benton1, Mia R Johns1, Emil Diamant1,2

  • 1Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT.

bioRxiv : the preprint server for biology
|November 26, 2025
PubMed
概括

研究人员开发了UCM-A86,一种新型的阳性全调节器,可选择性地增强含有GluN3子单元的甘氨酸激活N-甲基-D-酸盐 (NMDA) 受体. 这种新工具有助于研究GluN3 NMDA受体在大脑功能和神经发育中的作用.

关键词:
离子型谷氨酸受体 离子型谷氨酸受体通过全osteric 调制.发现药物的发现.链接离子通道的离子通道神经药理学神经药理学突触传输是突触传输的过程.

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