关于功能连接的时间稳定性和大脑状态稳定性,小鼠主要视觉区域V1与更高视觉区域AL相比
Mario Alexios Savaglio1,2, Christina Brozi1,2, Stelios M Smirnakis3
1Department of Computer Science, University of Crete, Greece.
bioRxiv : the preprint server for biology
|November 26, 2025
概括
高级视觉区域前侧区域 (AL) 的功能连接性比初级视觉皮层 (V1) 在时间和大脑状态之间更稳定. 在这里,我们可以看到AL AL AL AL AL.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 视觉皮层功能 视觉皮层功能
背景情况:
- 了解视觉皮层中的神经协调是信息处理的关键.
- 高级视觉区域 (例如,AL) 与V1.1相比,具有不同的角色和持续的表示.
- 功能连接架构在跨时代和跨状态的更高阶区域的稳定性不太清楚.
研究的目的:
- 为了比较V1和AL之间不同大脑状态的功能连接架构的稳定性.
- 研究视觉刺激和休息状态如何影响这些区域的功能连接.
- 确定兴奋对V1与AL的功能连接性的影响.
主要方法:
- 在小鼠体内进行双光子介质镜像成像.
- 同时记录V1和AL的神经元活动.
- 在视觉刺激和静止状态下,使用尖峰时系数 (STTC) 分析功能连接.
主要成果:
- 随着时间的推移,AL中的功能连接总是比V1.0更强大.
- 与V1.1相比,AL的功能连接结构在刺激和静止状态之间变化较小.
- 在休息期间,AL活动和连接性不受瞳孔大小 (唤醒) 的影响,而不是V1.
结论:
- 高阶区域AL中的功能连接性比V1.1更稳定,不那么依赖状态.
- 在AL中的自发活动更好地反映了刺激引起的网络架构.
- 与V1相比,唤起对AL的调节效果较弱,这表明网络动态不同.
更多相关视频
08:42Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
11.2K
11:57Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
Published on: February 24, 2021
11.4K
相关概念视频
01:14Motor and Sensory Areas of the Cortex
8.1K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
8.1K
01:21Association Areas of the Cortex
10.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.2K