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贝叶斯推理框架用于从活性膜中确定皮肤材料属性in vivo

Mark Wilkinson¹, Khushal Goparaju², Laura Nunez-Alvarez³

¹School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.

bioRxiv : the preprint server for biology

|November 26, 2025

概括

这项研究引入了一种新的贝叶斯框架,使用活性膜来准确地测量患者特定的皮肤机械性质. 该方法在没有直接力测量的情况下推断生物机械参数,增强皮肤学和外科诊断.

科学领域:

生物医学工程生物医学工程
皮肤病学皮肤病学
计算力学计算力学计算力学

背景情况:

精确的皮肤机械特性体内表征对于皮肤病学和外科手术至关重要.
目前的非侵入性方法难以捕捉皮肤复杂的非线性和异构性行为.

研究的目的:

开发一种新的贝叶斯推理框架,用于患者特定的皮肤生物力学评估.
克服现有技术在表征非线性和异构性皮肤特性方面的局限性.

主要方法:

利用活性膜诱导受控的皮肤变形,用于属性推断.
开发了一种皮肤膜相互作用的有限元模型 (FEM),用Holzapfel-Gasser-Ogden模型进行参数化.
使用主要组件分析和高斯过程回归构建了一个数据驱动的替代模型,以加速贝叶斯抽样.

主要成果:

启用了关键皮肤参数的概率推断:剪切模量,纤维刚度,分散和方向.
在合成研究中,即使在中度噪声下,也证明了准确的参数恢复.
表明多或多膜观测显著提高了参数识别能力.

结论:

拟议的活性膜平台提供了一种可行的方法,用于在体内进行非侵入性皮肤生物力学评估.
该方法成功地推断了皮肤生物力学,没有直接的力测量,依赖于已知的膜性质和应变场测量.

关键词:

贝叶斯的推理是贝叶斯的推理.反向问题逆向问题材料表征材料表征皮肤力学皮肤力学代理模拟代理模拟

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