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相关概念视频

The Extracellular Matrix01:42

The Extracellular Matrix

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Overview
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The Extracellular Matrix01:29

The Extracellular Matrix

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Extracellular Matrix01:26

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications
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输液式细胞外矩阵生物材料增强了急性心肌梗塞后的细胞特异性亲修复反应.

Joshua M Mesfin1, Alexander Chen2, Quincy P Lyons1

  • 1Shu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, Sanford Stem Cell Institute, University of California San Diego, La Jolla, California 92037, United States.

bioRxiv : the preprint server for biology
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PubMed
概括
此摘要是机器生成的。

这项研究揭示了血管内注入细胞外矩阵 (iECM) 如何促进心肌梗塞后的心脏修复. 单核RNA测序确定了关键的细胞机制,包括巨细胞激活和改善血管化,支持iECM作为一个有前途的疗法.

关键词:
生物材料是一种生物材料.脱细胞化的细胞外矩阵.一个可燃的输入器.心肌梗塞的心脏病发作这就是 snRNAseqq.这是一种治疗疗法.

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科学领域:

  • 再生医学是一种再生医学.
  • 生物材料科学 生物材料科学
  • 心血管研究研究心血管研究

背景情况:

  • 心肌梗塞 (MI) 引起显著的病理影响.
  • 脱细胞化细胞外基质 (ECM) 生物材料在心脏修复方面表现有前途.
  • 基于ECM的疗法的精确细胞和分子机制在很大程度上仍然未知.

研究的目的:

  • 调查静脉注入式ECM (iECM) 生物材料的治疗效应.
  • 阐明iECM介导的心脏修复背后的细胞和分子机制.
  • 为了确定iECM对心脏各类细胞类型的后MI的影响.

主要方法:

  • 开发和注入亲修复性脱细胞化ECM生物材料 (iECM).
  • 应用单核RNA测序 (snRNAseq) 来分析心脏细胞在急性时间点 (1,3,7日输液后).
  • 使用空间转录组学验证发现.

主要成果:

  • iECM治疗促进了前修复性巨细胞激活和纤维细胞重塑.
  • 观察到血管发育和淋巴血管生成的显著增加.
  • 在对iECM的反应中发现了心脏保护和神经发生的证据.
  • snRNAseq和空间转录组学提供了详细的细胞和分子见解.

结论:

  • 脱细胞化ECM生物材料,特别是iECM,在心脏环境中表现出显著的亲修复性质.
  • 这项研究定义了以前未被发现的iECM介导的治疗途径.
  • iECM显示出作为心肌梗塞的新疗法的巨大潜力.