扩展的杏仁核神经元的一个明显的亚群驱动食物摄入量
Isaac F Kandil1, Ethan T Rogers1, Allison R Morningstar1
1Wu Tsai Neurosciences Institute and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.
bioRxiv : the preprint server for biology
|November 26, 2025
概括
血管活性肠道受体2 (Vipr2) 神经元在末的圆床核促进食. 食物限制激活了这些神经元,这些神经元投射到下丘脑的养中心.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经内分泌学神经内分泌学
背景情况:
- 带终端细胞 (ovBNST) 床核的圆亚核集成了压力和奖励信号,以调节动机行为,包括食.
- 特定的ovBNST神经元子群,有助于养调节,仍然不太了解.
研究的目的:
- 研究表达ovBNST神经元的血管活性肠受体2 (Vipr2) 在调节食物摄入中的作用.
- 阐明神经回路和上游信号调节这些神经元.
主要方法:
- 化学遗传学使用DREADDs来激活ovBNST Vipr2神经元.
- 在Vipr2-tdTomato记者小鼠中的免疫组织化学和cFos激活映射.
- 病毒电路跟踪,以识别来自ovBNST Vipr2神经元的投射.
主要成果:
- 对ovBNST Vipr2神经元的化学遗传激活显著增加了食物摄入量.
- 食物限制强烈激活了ovBNST Vipr2神经元,与VIP内化减少有关.
- Vipr2和PKCδ标志着不同的ovBNST神经元群体,对养产生相反的影响.
- ovBNST Vipr2神经元向下丘脑的副下丘脑核 (PSTN) 和副腹腔核 (PVN) 发射.
结论:
- ovBNST Vipr2神经元是一个独特的亚群,促进食.
- 这些神经元因食物限制而被激活,并将BNST神经信号与下丘脑的养中心联系起来.
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