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相关概念视频

Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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感应合和压缩中的功率波动.

Dimitris A Pinotsis1, Sankaraleengam Alagapan2, Parisa Sarikhani2

  • 1Centre for Clinical, Social and Cognitive Neuroscience and Department of Psychology and Neuroscience, City St George's-University of London, London EC1V 0HB, United Kingdom.

bioRxiv : the preprint server for biology
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概括

深度大脑刺激 (DBS) 对大脑活动产生了急性影响. 对神经动态,不稳定频率和相对流浪时间的新测量可以预测DBS后抑郁症症状的严重程度.

关键词:
在 DBS 中,DBS 是 DBS 的代名词.利亚普诺夫指数的指数抑郁 抑郁症 抑郁症 抑郁症 抑郁症电场是指电场中的电场.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 精神病学是一个精神病学.

背景情况:

  • 深度大脑刺激 (DBS) 在植入手术后显示出急性行为影响,在没有持续刺激的情况下持续存在.
  • 局部场势 (LFP) 数据中的β功率波动被认为是DBS暴露后抑郁症的潜在生物标志物.
  • 目前缺乏对这些功率波动背后的神经动态的详细理解.

研究的目的:

  • 研究大脑功率波动与大脑漫游之间的关系,定义为神经活动在稳定和不稳定状态之间过渡.
  • 引入和验证两种新的动态系统指标,即不稳定频率和相对漫游时间,用于描述这些神经动态.
  • 探索这些措施在区分抑郁症症状严重程度方面的潜力.

主要方法:

  • 在DBS植入后一个月内从下带皮层 (SCC) 记录的LFP数据的分析,没有进一步的刺激.
  • 应用两个新的动态系统指标:不稳定频率和相对漫游时间,以描述神经活动动态.
  • 这些指标与汉密尔顿抑郁症评分表 (HDRS) 在一小群患者中得分的相关性.

主要成果:

  • 这项研究引入了不稳定频率和相对流浪时间作为测量神经活动和中大尺度振荡电场之间的相互作用.
  • 这两项措施表明,在分析的患者群体中,能够区分低和高的HDRS得分.
  • 这些发现在理论上是基于细胞电气合假设,将电场与信息处理和抑郁联系起来.

结论:

  • 不稳定频率和相对流浪时间为量化与大脑流浪相关的神经动态提供了一种新的方法.
  • 这些措施表明,在初始DBS暴露后,抑郁症症状严重程度的潜在指标是有前途的.
  • 需要进一步的研究来确定这些措施是否反映了快速抗抑郁作用的一般机制.