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Updated: Jan 10, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Published on: December 29, 2021

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一个热稳定的T7RNA聚合酶的计算重新设计

Zachary T Baumer1, Timothy A Whitehead1

  • 1Department of Chemical and Biological Engineering, University of Colorado Boulder; Boulder, 80305, USA.

bioRxiv : the preprint server for biology
|November 26, 2025
PubMed
概括

我们使用计算设计设计设计了一种高度稳定的T7 RNA聚合酶 (T7 RNAP),实现了创纪录的54.9°C的功能稳定性. 这种增强的酶保持了显著的活性,推动了生物技术应用.

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