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Updated: Jan 10, 2026

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氧化素1保护核基因组免受氧化损伤

Takashi Furusawa1, Vaibhavi Gujar1, Shalu Sharma2

  • 1Developmental Therapeutics Branch, NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.

bioRxiv : the preprint server for biology
|November 26, 2025
PubMed
概括

过氧化素1 (PRDX1) 缺乏导致基因组不稳定性,通过损害核糖体生物发生和核细胞完整性. 丢失PRDX1激活了DNA损伤反应,促进了二次DNA结构,影响了核糖体DNA转录.

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