呼吸道疾病中的互白素-37:分子机制和免疫调节
Jing Cao1, Kun He1, Zixiao Chen1
1The First Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Respiratory Critical Care Medicine, Hebei Institute of Respiratory Diseases, Shijiazhuang, Hebei, China.
Frontiers in immunology
|November 26, 2025
概括
介素-37 (IL-37) 是一种强大的抗炎细胞因子. 这篇评论强调了IL-37在喘,感染,肺癌和纤维化等呼吸道疾病中的保护作用,提供了治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
背景情况:
- 介素-37 (IL-37) 是一种强大的抗炎细胞因子,具有双重细胞内和细胞外功能.
- IL-37在调节免疫反应中起着重要作用,并且在各种疾病中表现出保护作用.
研究的目的:
- 审查IL-37在常见呼吸道疾病中的多方面的作用.
- 总结 IL-37 在呼吸系统中作用的基础分子机制.
- 讨论针对呼吸系统疾病的IL-37的治疗潜力.
主要方法:
- 关于在呼吸系统疾病中研究IL-37的研究的文献综述.
- 分析IL-37在喘,肺部感染,非小细胞肺癌 (NSCLC) 和肺纤维化中的机制.
- 关于IL-37免疫调节功能的现有研究的系统摘要.
主要成果:
- 通过抑制Th2/Th17反应和TSLP/IL-33释放,以及减弱气道重塑,IL-37可以缓解喘.
- 在肺部感染 (COVID-19,流感,结核病,真菌) 中,IL-37减轻高炎症,抑制病毒复制,并调节免疫病理.
- IL-37抑制NSCLC的增殖和迁移,并抑制瘤的进展;它还通过减少原体沉积和促进自来对抗肺纤维化.
结论:
- IL-37作为一个关键的免疫调节剂,在一系列的呼吸系统疾病中起作用.
- 向IL-37为呼吸系统医学中的临床干预提供了新的战略机会.
- 对IL-37的机制进行进一步的研究可以释放它对肺部疾病的全部治疗潜力.
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